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Selected Recent Publications

1.         Young, L.C., D.W. McDonald, and M.J. Hendzel, Kdm4b histone demethylase is a DNA damage response protein and confers a survival advantage following gamma-irradiation. J Biol Chem, 2013. 288(29): p. 21376-88.http://www.ncbi.nlm.nih.gov/pubmed/23744078
2.         Young, L.C. and M.J. Hendzel, The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression. Biochem Cell Biol, 2013. 91(6): p. 369-77.http://www.ncbi.nlm.nih.gov/pubmed/24219278
3.         Raghuram, N., H. Strickfaden, D. McDonald, K. Williams, H. Fang, C. Mizzen, J.J. Hayes, J. Th'ng, and M.J. Hendzel, Pin1 promotes histone H1 dephosphorylation and stabilizes its binding to chromatin. J Cell Biol, 2013. 203(1): p. 57-71.http://www.ncbi.nlm.nih.gov/pubmed/24100296
4.         Ismail, I.H., D. McDonald, H. Strickfaden, Z. Xu, and M.J. Hendzel, A Small Molecule Inhibitor of Polycomb Repressive Complex 1 Inhibits Ubiquitin Signaling at DNA Double-strand Breaks. J Biol Chem, 2013. 288(37): p. 26944-54.http://www.ncbi.nlm.nih.gov/pubmed/23902761
5.         Hendzel, M.J. and R.A. Greenberg, Conversations between chromatin modifications and DNA double strand break repair: a commentary. Mutat Res, 2013. 750(1-2): p. 1-4.http://www.ncbi.nlm.nih.gov/pubmed/23994712
6.         Campbell, S., I.H. Ismail, L.C. Young, G.G. Poirier, and M.J. Hendzel, Polycomb repressive complex 2 contributes to DNA double-strand break repair. Cell Cycle, 2013. 12(16): p. 2675-83.http://www.ncbi.nlm.nih.gov/pubmed/23907130
7.         Ismail, I.H., J.P. Gagne, M.C. Caron, D. McDonald, Z. Xu, J.Y. Masson, G.G. Poirier, and M.J. Hendzel, CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage. Nucleic Acids Res, 2012. 40(12): p. 5497-510.http://www.ncbi.nlm.nih.gov/pubmed/22402492
8.         Andrin, C., D. McDonald, K.M. Attwood, A. Rodrigue, S. Ghosh, R. Mirzayans, J.Y. Masson, G. Dellaire, and M.J. Hendzel, A requirement for polymerized actin in DNA double-strand break repair. Nucleus, 2012. 3(4): p. 384-95.http://www.ncbi.nlm.nih.gov/pubmed/22688650
9.         Gieni, R.S., I.H. Ismail, S. Campbell, and M.J. Hendzel, Polycomb group proteins in the DNA damage response: a link between radiation resistance and "stemness". Cell Cycle, 2011. 10(6): p. 883-94.http://www.ncbi.nlm.nih.gov/pubmed/21346409
10.       Raghuram, N., G. Carrero, T.J. Stasevich, J.G. McNally, J. Th'ng, and M.J. Hendzel, Core histone hyperacetylation impacts cooperative behavior and high-affinity binding of histone H1 to chromatin. Biochemistry, 2010. 49(21): p. 4420-31.http://www.ncbi.nlm.nih.gov/pubmed/20411992
11.       Ismail, I.H., C. Andrin, D. McDonald, and M.J. Hendzel, BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair. J Cell Biol, 2010. 191(1): p. 45-60.http://www.ncbi.nlm.nih.gov/pubmed/20921134
12.       Heit, R., J.B. Rattner, G.K. Chan, and M.J. Hendzel, G2 histone methylation is required for the proper segregation of chromosomes. J Cell Sci, 2009. 122(Pt 16): p. 2957-68.http://www.ncbi.nlm.nih.gov/pubmed/19638412
13.       Gieni, R.S. and M.J. Hendzel, Actin dynamics and functions in the interphase nucleus: moving toward an understanding of nuclear polymeric actin. Biochem Cell Biol, 2009. 87(1): p. 283-306.http://www.ncbi.nlm.nih.gov/pubmed/19234542
14.       Gieni, R.S. and M.J. Hendzel, Polycomb group protein gene silencing, non-coding RNA, stem cells, and cancer. Biochem Cell Biol, 2009. 87(5): p. 711-46.http://www.ncbi.nlm.nih.gov/pubmed/19898523
15.       Ismail, I.H. and M.J. Hendzel, The gamma-H2A.X: is it just a surrogate marker of double-strand breaks or much more? Environ Mol Mutagen, 2008. 49(1): p. 73-82.http://www.ncbi.nlm.nih.gov/pubmed/18095327